Acetohydroxamic Acid CAS 546-88-3 EINECS NO 208-913-8

Product Description:

Product Name: Acetohydroxamic acid CAS NO: 546-88-3

Synonyms:

methanecarbohydroxamic acid;

N-acetylhydroxylamine;

Chemical & Physical Properties:

Appearance: White Crystalline Solid

Assay :≥99.0%

Density: 1.155g/cm3

Boiling Point: 231.4℃ at 760 mmHg

Melting Point: 86-90℃

Refractive Index: 1.42

Water Solubility: Soluble in water.

Sensitive: Hygroscopic

Stability: Stable under normal temperatures and pressures.

Storage Condition: Store in a cool, dry place. Store in a tightly closed container.

Safety Information:

RTECS: AK8157000

Safety Statements: S45-S53

HS Code: 2942000000

WGK Germany: 3

Packing Group: II

RIDADR: 3263

Risk Statement: R61

Hazard Code: T

A urease inhibitor. Used in the synthesis of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors. Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.

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