Nifedipine CAS 21829-25-4

Product Description:

Product Name: Nifedipine CAS NO: 21829-25-4

Synonyms:

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Dimethyl Ester;

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;

Chemical & Physical Properties:

Appearance: Yellow Crystalline Solid

Assay :≥99.0%

Density: 1.271g/cm3

Boiling Point: 475.3℃ at 760 mmHg

Melting Point: 171-175℃

Flash Point: 241.2℃

Refractive Index: 1.584

Stability: Stable under normal temperatures and pressures.

Storage Condition: 2-8℃

Vapor Pressure: 2.68E-08mmHg at 25℃

Safety Information:

RTECS: US7975000

Safety Statements: S26-S36

HS Code: 2933290090

WGK Germany: 1

Risk Statement: R22

Hazard Codes: Xn,Xi

Signal Word: Warning

Hazard Declaration: H302

Symbol: GHS07

Nifedipine, sold under the brand names Adalat among others, is a medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in preterm labor may allow more time for steroi-ds to improve the baby's lungs and time to transfer the mother to a well qualified medical facility before delivery. Nifedipine is taken by mouth and comes in fast and slow release formulations.

Common side effects include lightheadedness, headache, feeling tired, leg swelling, cough, and shortness of breath. Serious side effects may include low blood pressure and heart failure. There is tentative evidence that its use in pregnancy is safe; however, it is not recommended during breastfeeding. It is a calcium channel blocker of the dihydropyridine type.

Nifedipine was discovered in 1969 and approved for use in the United States in 1981. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale price in the developing world for the slow release form is about 1.90 to 3.80 USD per month. In the United States it is about 40 to 60 USD a month depending on the dose.

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