Guanidine Hydrochloride CAS 50-01-1

Product Description:

Product Name: Guanidine hydrochloride CAS NO: 50-01-1

Synonyms:

Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride;

Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride;

guanidine monohydrochloride;

Chemical & Physical Properties:

Appearance: White cryst. powder

Assay :≥99.00%

Density: 1.34

Boiling Point: 132.9℃ at 760 mmHg

Melting Point: 179-186℃

Flash Point: 34.2℃

Refractive Index: n20/D 1.465

Water Solubility: 2280 g/L (20℃)

Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents.

Storage Condition: Store at RT.

Sensitive: Hygroscopic

Safety Information:

RTECS: MF4300000

Safety Statement: S22

HS Code: 2925290090

WGK Germany: 1

Risk Statements: R22; R36/38

Hazard Codes: Xn,Xi

Hazard Declaration: H302 + H332; H315; H319

Symbol: GHS07

Signal Word: Warning

Caution Statements: P261; P280; P301 + P312 + P330; P304 + P340 + P312; P305 + P351 + P338; P337 + P313

Guanidinium chloride or guanidine hydrochloride, usually abbreviated GdmCl and sometimes GndCl or GuHCl, is the hydrochloride salt of guanidine. Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase.

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