Reserpine CAS 50-55-5

Product Description:

Product Name: Reserpine CAS NO: 50-55-5

Synonyms:

Yohimban-16-carboxylic acid, 11,17-dimetho-xy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3α,16α,17-,18α,20-)-;

methyl reserpate 3,4,5-trimethoxybenzoic acid ester;

methyl (1R,15S,17R,18R,19S,20S)-6,18-dimetho-xy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;

Chemical & Physical Properties:

Appearance: Light yellow powder

Assay :≥99.00%

Density: 1.32g/cm3

Boiling Point: 700.1℃ at 760mmHg

Melting Point: 265℃ (dec.)

Flash Point: 377.2℃

Stability: Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents.

Storage Condition: 2-8℃

Safety Information:

Safety Statement: S26

HS Code: 3003909090

Packing Group: II

RIDADR: UN 1219

Risk Statements: R10; R36; R67

Hazard Code: Xi

Caution Statements: P301 + P312 + P330

Symbol: GHS07

Signal Word: Warning

Hazard Declaration: H302

Reserpine (also known by trade names Raudixin, Serpalan, Serpasil) is an indole alkaloid, antipsychotic, and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. The antihypertensive actions of reserpine are a result of its ability to deplete catecholamines (among other monoamine neurotransmitters) from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral vascular resistance.

Reserpine-mediated depletion of monoamine neurotransmitters in the synapses is often cited as evidence to the theory that depletion of the monoamine neurotransmitters causes subsequent depression in humans (c.f. monoamine hypothesis). However, this claim is not without controversy. The reserpine-induced depression is considered by some researchers to be a myth, while others claim that teas made out of the plant roots containing reserpine have a calming, sedative action that can actually be considered antidepressant. Notably, reserpine was the first compound shown to be an effective antidepressant in a randomized placebo-controlled trial.

Moreover, reserpine has a peripheral action in many parts of the body, resulting in a preponderance of the effects of the cholinergic part of the autonomous nervous system on the GI tract, smooth muscles, blood vessels, etc.

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