Amlodipine Besylate CAS 111470-99-6

Product Description:

Product Name: Amlodipine Besylate CAS NO: 111470-99-6

Synonyms:

benzenesulfonic acid,3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate;

3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona;

Chemical & Physical Properties:

Appearance: White powder

Assay :≥99.00%

Density: 1.227g/cm3

Boiling Point: 527.2℃ at 760 mmHg

Melting Point: 199-201℃

Flash Point: 272.6℃

Vapor Pressure: 3.34E-11mmHg at 25℃

Water Solubility: Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.

Safety Information:

RTECS: US7967700

Safety Statements: S26; S36

HS Code: 2933990090

WGK Germany: 3

Risk Statements: R22

Hazard Code: Xn

Amlodipine besylate (ADB) is an important secondgeneration calcium channel blocker that belongs to the dihydropyridine family. It is used for the treatment of hypertension and angina. It is more selective for arterial vascular smooth muscle than for the cardiac tissue. It is approved for the treatment of hypertension and for variant and stable angina and may also be used for dilated cardiomyopathy. ADB has ameliorating effects on the plasma and myocardial catecholamine levels and significantly reduces calcium deposition. It has a negative inotropic effect on the heart that results in a decrease in heart work load.

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