Piperaquinoline CAS 4085-31-8

Product Description:

Product Name: Piperaquinoline CAS NO: 4085-31-8

Synonyms:

7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline;

Piperaquine tetraphosphate tetrahydrate;

Chemical & Physical Properties:

Appearance: Off-white powder

Assay :≥99.00%

Density: 1.292g/cm3

Boiling Point: 721.1℃ at 760 mmHg

Flash Point: 389.9℃

Refractive Index: 1.664

Vapour Pressure: 0.0±2.3 mmHg at 25℃

Safety Information:

HS Code: 2942000000

Piperaquine is an antimalarial drug, a bisquinoline first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. Usage declined in the 1980s as piperaquine-resistant strains of P. falciparum arose and artemisinin-based antimalarials became available. However, Chinese scientists have been studying whether piperaquine can still be used therapeutically in combination with artemisinin.

Piperaquine is characterized by slow absorption and a long biological half-life, making it a good partner drug with artemisinin derivatives which are fast acting but have a short biological half-life.

The fixed-dose combination dihydroartemisinin-piperaquine (Eurartesim) was submitted for approval to the European Medicines Agency in 2009.

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