Lamotrigine CAS 84057-84-1

Product Description:

Product Name: Lamotrigine CAS NO: 84057-84-1

Synonyms:

HYDROXYMETHYL PROGESTERONE;

6-O-TRITYL-1,2,3,4-TETRA-O-ACETYL-ALPH-A-D-MANNOPYRANOSE;

1,2,4-TRIAZINE-3,5-DIAMINE,6-(2,3-DICHLOROPHENYL)-;

Chemical & Physical Properties:

Appearance: White crystallization

Assay :≥99.00%

Density: 1.572 g/cm3

Boiling Point: 503.1℃ at 760 mmHg

Melting Point: 177-181℃

Flash Point: 258.1℃

Stability: Stable at normal temperatures and pressures.

Storage Condition: 2-8℃

Safety Information:

RTECS: XY5850700

Hazard Class: 6.1(b)

Safety Statements: S45-36-26

HS Code: 2933699090

Packing Group: III

WGK Germany: 3

RIDADR: UN 2811 6

Risk Statement: R25

Hazard Code: T

An anticonvulsant. Inhibits glutamate release, possible through inhibition of Sodium, Potassium and Calcium currents. Used in treatment of bipolar depression. Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated .

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