Ketotifen Fumarate CAS 34580-14-8 White to Off-White Crystalline Powder

Product Description:

Product Name: Ketotifen fumarate CAS NO: 34580-14-8

Synonyms:

(E)-but-2-enedioicacid,10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;

Ketotifen hydrogen fumarate;

Zaditor;

Chemical & Physical Properties:

Appearance: White to off-white crystalline power

Assay :≥99.00%

Density: 1.236g/cm3

Boiling Point: 488.9℃ at 760 mmHg

Melting Point: 191—195℃

Flash Point: 249.5℃

Refractive Index: n20/D 1.522(lit.)

Water Solubility: Soluble in water (10 mg/ml), DMSO (100 mM), and methanol.

Safety Information:

RTECS: DE8260000

Safety Statement: S36

HS Code: 2934999090

WGK Germany: 3

Risk Statement: R22

Hazard Code: Xn

Signal Word: Warning

Symbol: GHS07

Hazard Declaration: H302

Ketotifen is used as an antiasthmatic. Ketotifen is an antiallergic agent. Ketotifen (fumarate) is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer, which is used to prevent asthma attacks.Target: Histamine Receptor Ketotifen is a second-generation noncompetitive H1-antihistamine and mast cell stabilizer. It is most commonly sold as a salt of fumaric acid,ketotifen fumarate, and is available in two forms. In its ophthalmic form, it is used to treat allergic conjunctivitis, or the itchy red eyes caused by allergies. In its oral form, it is used to prevent asthma attacks. Side effects include drowsiness, weight gain, dry mouth, irritability, and increased nosebleeds.Ketotifen relieves and prevents eye itchiness and/or irritation associated with most seasonal allergies. It starts working within minutes after administering the drops. The drug has not been studied in children under three. The mean elimination half life is 12 hours. Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor. The drug may also help relieve the symptoms of Irritable bowel syndrome.

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