Trimethyl Orthoformate CAS 149-73-5

Product Description:

Product Name: Trimethyl Orthoformate CAS NO: 149-73-5

Synonyms:

anhydrous trimethyl orthoformate;

Orthoformic Acid Trimethyl Ester;

Methyl orthoformate;

Chemical & Physical Properties:

Appearance: Colorless transparent liquid

Assay :≥99.0%

Density: 0.97

Boiling Point: 101-102℃

Melting Point: -53℃

Flash Point: 13℃

Refractive Index: 1.378-1.38

Sensitive: Moisture sensitive

Water Solubility: 10 g/L (hydrolysis)

Stability: Stable at room temperature in closed containers under normal storage and handling conditions.

Storage Condition: Store at RT.

Vapor Density: 3.67 (vs air)

Vapor Pressure: 23.5 mm Hg ( 20℃)

Safety Information:

RTECS: RM6650000

Hazard Class: 3

Safety Statements: S16-S26-S29-S9

HS Code: 2915130000

Packing Group: II

WGK Germany: 1

RIDADR: UN 3272 3

Risk Statements: R11; R36

Hazard Codes: F,Xi

Hazard Declaration: H225; H319

Signal Word: Danger

Symbols: GHS02, GHS07

Caution Statements: P210; P305 + P351 + P338

Trimethyl orthoformate is the simplest orthoester. It is a reagent used in organic synthesis for the introduction of a protecting group for aldehydes. The product of reaction of an aldehyde with trimethyl orthoformate is an acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.The industrial synthesis of this chemical is from hydrogen cyanide and methanol.Trimethyl orthoformate is a useful building block for creating methoxymethylene groups and heterocyclic ring systems. It introduces a formyl group to a nucleophilic substrate, e.g. RNH2 to form R-NH-CHO, which can undergo further reactions. It is used in the production of the fungicides, azoxystrobin and picoxystrobin, as well as for some members of the floxacin family of antibacterial drugs. A number of pharmaceutical intermediates are also made from trimethyl orthoformate.

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