Betahistine Mesylate CAS 54856-23-4 API Active Pharmaceutical Ingredient

Product Description:

Product Name: Betahistine Mesylate CAS NO: 54856-23-4                        

Synonyms:

methanesulfonic acid,N-methyl-2-pyridin-2-ylethanamine;

n-methyl-2-pyridineethanamindimethanesulfonate;

Chemical & Physical Properties:

Appearance: White or almost white, crystalline powder, very hygroscopic.

Assay :≥99.0%

Boiling Point: 210.9℃ at 760 mmHg

Melting Point: 112℃

Flash Point: 96.7℃

Water Solubility: Almost transparency

Safety Information:

RTECS: UT2970200

HS Code: 2933399090

Toxicity: LD50 orl-rat: 3030 mg/kg NIIRDN 6,750,82

Betastastine mesylate is a commonly used clinical drug with definite effect. As a vasodilator, it is a derivative of histamine and has similar chemical structure and pharmacological properties to histamine. It is a weak agonist of histamine H1 receptor, but has no effect on histamine H2 receptor, and is a strong agonist of histamine H3 receptor. Therefore, it can selectively act on the histamine H1 receptor and dilate the anterior capillary Chemicalbook vasculature dilator muscle, thereby increasing the blood flow to the vascular microcirculation. In addition, it can selectively increase the microcirculation of brain, cerebellum, brainstem and inner ear, adjust the capillary permeability of inner ear, increase the blood flow to the vestibule of inner ear and brain, reduce the venous pressure of inner ear, thus accelerating the absorption of inner ear lymphatic, and further increase the blood flow of inner ear artery, so as to relieve the symptoms of vertigo.

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