PYRIDOSTIGMINE BROMIDE CAS 101-26-8 API Active Pharmaceutical Ingredient

Product Description:

Product Name: PYRIDOSTIGMINE BROMIDE CAS NO: 101-26-8                     

Synonyms:

3-((Dimethylcarbamoyl)oxy)-1-methylpyridin-1-ium bromide;

mestinonebromide;

PyridostigMine BroMide;

Chemical & Physical Properties:

Appearance: Pale yellow to colorless liquid or white solid

Assay :≥99.0%

Density: 0.9613 g/cm3 (20℃)

Boiling Point: 88 (25 torr)

Melting Point: 154℃

Refractive Index: 1.48 (20℃)

Stability: Stable at normal temperatures and pressures in in a tightly sealed container.

Storage Condition: Keep in a cool, dry location in a tightly closed container when not in use.

Safety Information:

RTECS: UU5270000

Safety Statements: S22; S36/37/39; S45

RIDADR: UN 2811 6.1/PG 2

Risk Statements: R26/27/28

WGK Germany: 3

Hazard Codes: T+

Hazard Class: 6.1

Packing Group: II

Cholinergic, used in the treatment of myasthenia gravis, and is a pre-exposure antidote to chemical warfare agents. Pyridostigmine bromide,3-hydroxy-1-methylpyridinium bromide dimethylcarbamateor pyridostigmine bromide (Mestinon), occurs as a white, hygroscopic,crystalline powder with an agreeable, characteristicodor. It is freely soluble in water, alcohol, and chloroform.

Pyridostigmine bromide is about one fifth as toxic asneostigmine. It appears to function in a manner similar tothat of neostigmine and is the most widely used anticholinesteraseagent for treating myasthenia gravis. Theliver enzymes and plasma cholinesterase metabolize thedrug. The principal metabolite is 3-hydroxy-N-methylpyridinium.Orally administered pyridostigmine has a half-lifeof 90 minutes and a duration of action of between 3 and6 hours.

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