Hydroxyzine 2HCl CAS 2192-20-3

Product Description:

Product Name: Hydroxyzine 2HCl CAS NO: 2192-20-3           

Synonyms:

2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol,dihydrochloride;

hydroxyzine hydrochloride;

Hydroxyzine dihydrochloride;

Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.0%

Density: 1.182 g/cm3

Boiling Point: 499.2℃ at 760 mmHg

Melting Point: 190-192℃

Flash Point: 255.7℃

Storage Condition: Refrigerator

Vapor Pressure: 8.78E-11mmHg at 25℃

Safety Information:

RTECS: KK2280000

Safety Statement: S26

HS Code: 2933990090

WGK Germany: 3

Risk Statements: R22; R36/37/38

Hazard Code: Xn

H1 receptor antagonist. Anxiolytic. Antihistaminic. Hydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE). Hydroxyzine (500 M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 g/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3].Hydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of Morphin/e on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates Morphin/e on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases Morphin/e antinociception in rats.

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