Meclizine Dihydrochloride CAS 1104-22-9 EINECS NO 214-164-8

Product Description:

Product Name: Meclizine dihydrochloride CAS NO: 1104-22-9          

Synonyms:

bonamine;

Navidoxine;

ancolandihydrochloride;

Chemical & Physical Properties:

Appearance: White,slightly yellowish,crystalline powder

Assay :≥99.0%

Density: 1.159g/cm3

Boiling Point: 495.3℃ at 760mmHg

Flash Point: 253.3℃

Storage Condition: 2-8℃

Vapor Pressure: 6E-10mmHg at 25℃

Safety Information:

RTECS: TL2005000

Safety Statements: S22-36

HS Code: 2933499090

WGK Germany: 3

Risk Statement: R22

Hazard Code: Xn

Symbols: GHS07, GHS08

Signal Word: Warning

Caution Statement: P281

Hazard Declaration: H302; H361

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sicknessTarget: Histamine H1 ReceptorMeclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, possesses anticholinergic, central nervous system depressant, and local anesthetic effects. Meclizine is an agonist ligand for mouse CAR (constitutive androstane receptor), and an inverse agonist for human CAR. Meclizine increases mCAR transactivation in a dose-dependent manner, stimulates binding of ster-oid receptor coactivator 1 to the murine receptor in vitro. In contrast, meclizine suppresses hCAR transactivation and inhibits the pheno-bar-bital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.

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