HEXAMETHONIUM BROMIDE CAS 55-97-0 Chemical Intermediates

Product Description:

Product Name: HEXAMETHONIUM BROMIDE CAS NO: 55-97-0

Synonyms:

Hexamethonium bromide,N,N,N,N',N',N'-Hexamethylhexamethylenediammoniumdibromide;

gangliostat;

Methobromine;

Chemical & Physical Properties:

Appearance: White crystalline powder and agglomerates

Assay :≥99.00%

Melting Point: -285℃ (dec.)

Storage Condition: Desiccate at RT

Safety Information:

RTECS: BQ8575000

Safety Statements: S22; S24/25

WGK Germany: 2

Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3].

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