Pioglitazone Hydrochloride CAS 112529-15-4

Product Description:

Product Name: Pioglitazone hydrochloride CAS NO: 112529-15-4

Synonyms:

5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione hydrochloride;

Effects of pioglitazone;

5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride;

Chemical & Physical Properties:

Appearance: White crystals or crystalline powder

Assay :≥99.00%

Density: 1.26 g/cm3

Boiling Point: 575.4℃ at 760 mmHg

Melting Point: 193-194℃

Flash Point: 301.8℃

Refractive Index: 1.64

Vapor Pressure: 0mmHg at 25℃

Safety Information:

Safety Statements: S22; S24/25

HS Code: 2933990090

Risk Statements: R36/38

Hazard Code: Xi

Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insulin dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thiourea. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insulin resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insulin, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insulin resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.