Olopatadine CAS 113806-05-6

Product Description:

Product Name: Olopatadine CAS NO: 113806-05-6

Synonyms:

11-((z)-3-(dimethyl-amino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid;

Olopatatadine;KW 4679;

Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-;

Chemical & Physical Properties:

Appearance: White or off-white crystalline powder

Assay :≥99.00%

Density: 1.221 g/cm3

Boiling Point: 523℃ at 760 mmHg

Flash Point: 270.1℃

Storage Condition: Store in original container in a cool dark place.

Vapour Pressure: 0.0±1.4 mmHg at 25℃

Index of Refraction: 1.641

Olopatadine hydrochloride is an antihistamine (as well as anticholinergic and mast cell stabilizer), sold as a prescription eye drop manufactured by Alcon in one of three strengths: 0.7% solution or Pazeo in the US, 0.2% solution or Pataday (also called Patanol S in some countries), and 0.1% or Patanol (also called Opatanol in some countries). It is used to treat itching associated with allergic conjunctivitis (eye allergies). A decongestant nasal spray formulation is sold as Patanase, which was approved by the FDA on April 15, 2008. It is also available as an oral tablet in Japan under the tradename Allelock, manufactured by Kyowa Hakko Kogyo.

It should not be used to treat irritation caused by contact lenses. The usual dose for Patanol is 1 drop in each affected eye 2 times per day, with 6 to 8 hours between doses. Both Pazeo and Pataday are dosed 1 drop in each eye daily.

There is potential for Olopatadine as a treatment modality for s-teroid rebound (red skin syndrome).

Olopatadine was developed by Kyowa Hakko Kogyo.

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