Narcotine CAS 128-62-1

Product Description:

Product Name: Narcotine CAS NO: 128-62-1

Synonyms:

[S-(R*,S*)]-6,7-Dim-ethoxy-3-(5,6,7,8-tetrahydro-4-m-ethoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-1(3H)-Isobenzofuranone;

1(3H)-Isobenzofuranone,6,7-dim-ethoxy-3-(5,6,7,8-tetrahydro-4-m-ethoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, [S-(R*,S*)]-;

Chemical & Physical Properties:

Appearance: Crystalline solid

Assay :≥99.00%

Density: 1.332g/cm3

Boiling Point: 565.3℃ at 760mmHg

Melting Point: 174-176℃

Flash Point: 295.7℃

Water Solubility: 302.9mg/L(25℃)

Vapor Pressure: 4.83E-14mmHg at 25℃

Storage temp.: -20℃ Freezer, Under Inert Atmosphere

Solubility: Practically insoluble in water, soluble in a-cetone, slightly soluble in ethanol (96 per cent). It dissolves in strong acids; on dilution of the solution with water, the base may be precipitated.

Safety Information:

Hazard Class: 6.1(b)

Packing Group: III

RIDADR: UN 1544

Risk Statement: R22

Hazard Code: Xn

Noscapine is an orally administrable drug used worldwide for cough suppression, primarily mediated by its σ-receptor agonist activity, and possess anticancer activity.Target: σ-receptorin vitro: Noscapine is a phthalideisoquinoline alkaloid from o-pium, is a recently discovered anticancer drug and is currently under investigation in phase-I/II clinical trials for the treatment of leukemia and lymphoma. Noscapine causes few or no side effects and has been widely used as a cough suppressant in developing countries. Noscapine has been demonstrated to interact with microtubules. Interestingly, unlike many other microtubule-targeting agents such as Paclitaxel and Nocodazole, Noscapine does not obviously affect the total amount of microtubule polymers in cells; instead, it significantly increases the time microtubules spend in the pause state. The alteration of microtubule dynamics then activates the spindle checkpoint and arrests cell cycle progression at mitosis, leading to apoptotic cell death.

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