Atenolol CAS 29122-68-7

Product Description:

Product Name: Atenolol CAS NO: 29122-68-7

Synonyms:

2-(4-(2-Hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide;

4-(2-hydroxy-3-[(1-methylethyl)amino]propoxy)benzeneacetamide;

1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol;

Chemical & Physical Properties:

Appearance: White to off-white crystalline solid

Assay :≥99.00%

Density: 1.125 g/cm3

Boiling Point: 508℃ at 760 mmHg

Melting Point: 154℃

Flash Point: 261.1℃

Storage Condition: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Vapor Pressure: 3.82E-11mmHg at 25℃

Safety Information:

RTECS: AC3600000

Safety Statements: S22; S24/25; S36; S26

HS Code: 2924299090

WGK Germany: 2

Risk Statements: R22; R36/37/38; R20/21/22

Hazard Code: Xn

Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers (sometimes written β-blockers), a class of drugs used primarily in cardiovascular diseases. Introduced in 1976, atenolol was developed as a replacement for propranolol in the treatment of hypertension. It works by slowing down the heart and reducing its workload. Unlike propranolol, atenolol does not readily pass through the blood–brain barrier, thus decreasing the incidence of central nervous system side effects.

Atenolol is one of the most widely used β-blockers in the United Kingdom and was once the first-line treatment for hypertension. However, recent studies indicate that atenolol may not reduce morbidity or mortality when used to treat hypertension, and may even increase mortality in some subgroups. In addition, the role for β-blockers in general in hypertension was downgraded in June 2006 in the United Kingdom, and later in the United States, as they are less appropriate than newer drugs, particularly in the elderly.

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