Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1297537-33-7
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15DAY
Payment Terms: L/C,D/A,D/P,Western Union,MoneyGram,T/T
Supply Ability: G,KG,TON
CAS NO:: |
1297537-33-7 |
Appearance:: |
Powder |
Molecular Formula:: |
C19H17ClN6O2 |
Molecular Weight:: |
396.83000 |
EINECS NO:: |
941-760-1 |
MDL NO:: |
MFCD29472275 |
CAS NO:: |
1297537-33-7 |
Appearance:: |
Powder |
Molecular Formula:: |
C19H17ClN6O2 |
Molecular Weight:: |
396.83000 |
EINECS NO:: |
941-760-1 |
MDL NO:: |
MFCD29472275 |
Product Description:
Product Name: ORM-15341 CAS NO: 1297537-33-7
Synonyms:
(S)-3-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-5-carboxamide;
ORM-15341;
(S)-5-acetyl-N-(1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide;
Chemical & Physical Properties:
Appearance: Powder
Assay :≥99.00%
Boiling Point: 714.7±60.0℃(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
Pka: 8.70±0.10(Predicted)
Solubility: DMSO: ＞ 37 mg/mL
Storage: -20℃ Freeze
ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an a-ndrogen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: a-ndrogen receptorin vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L).
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