Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 119615-63-3
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15DAY
Payment Terms: L/C,D/A,D/P,T/T,Western Union,MoneyGram
Supply Ability: G,KG,TON
CAS NO:: |
119615-63-3 |
Appearance:: |
Beige Solid |
Molecular Formula:: |
C14H13ClN4O2 |
Molecular Weight:: |
304.73200 |
EINECS NO:: |
634-250-2 |
MDL NO:: |
MFCD01749474 |
CAS NO:: |
119615-63-3 |
Appearance:: |
Beige Solid |
Molecular Formula:: |
C14H13ClN4O2 |
Molecular Weight:: |
304.73200 |
EINECS NO:: |
634-250-2 |
MDL NO:: |
MFCD01749474 |
Product Description:
Product Name: OLPRINONE HYDROCHLORIDE CAS NO: 119615-63-3
Synonyms:
Olprinone (Hydrochloride);
1,2-dihydro-5-imidazo<1,2-a>pyridin-6-yl-6-methyl-2-oxo-3-pyridine carbonitrile hydrochloride;
pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride;
Chemical & Physical Properties:
Appearance: Beige solid
Assay :≥99.00%
Density: 1.34g/cm3
Melting Point: >300℃
Storage Condition: 2-8℃
Safety Information:
Safety Statement: S26
Risk Statements: R36/37/38
Hazard Code: Xi
WGK Germany: 2
Inotropic agent which inhibits cAMP phosphodiesterase. Cardiotonic. Coatec was launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. There are three related synthetic routes, 5-6 steps each, to loprinone all converging on 1-(imidazo[1,2a]pyridyl-6-yl)-Zpropanone as an advanced intermediate. It is a potent and selective inhibitor of PDE Ⅲ and a long lasting, orally active, positive inotropic agent. The PDE Ⅲ inhibition caused increased levels of CAMP which leads to the positive inotropic effect that was not altered by β or H2-preceptor antagonists.
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