Tigecycline CAS 220620-09-7 for Effective Antibiotic Therapy

Product Description:

Product Name: Tigecycline CAS NO: 220620-09-7

Synonyms:

2-NAPHTHACENECARBOXAMIDE;

TIGECYCLINE POWDER;

WAY-GAR 936;

Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.00%

Density: 1.455 g/cm3

Boiling Point: 890.922℃ at 760 mmHg

Melting Point: 164-166℃

Flash Point: 492.612℃

Refractive Index: 1.675

Vapor Pressure: 0mmHg at 25℃

Safety Information:

Safety Statements: S24/25

HS Code: 3004909090

WGK Germany: 3

Packing Group: III

Tigecycline (INN) is an antibiotic used to treat a number of bacterial infections. It is a first in class glycylcycline that is administered intravenously. It was developed in response to the growing rate of Antibiotic resistance in bacteria such as Staphylococcus aureus, Acinetobacter baumannii, and E. coli. As a tetracycline derivative antibiotic, its structural modifications has expanded its therapeutic activity to include Gram-positive and Gram-negative organisms, including those of multi-drug resistance. It is approved to treat complicated skin and soft tissue infections (cSSTI), complicated intra-abdominal infections (cIAI), and community-acquired bacterial pneumonia (CAP) in individuals 18 years and older.

Tigecycline is a semi-synthetic tetracycline prepared by the introduction of a tert-butylaminoacetamido group into a previously unexplored and un-substituted region of existing tetracyclines. Like other tetracyclines, tigecycline acts by reversibly binding to the 30S ribosomal subunit and inhibits protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. The enhanced activity can be attributed to stronger binding affinity, thus minimising the impact of existing mechanisms of resistance. Tigecycline is regarded as the first of a new class of glycylcyline antibiotics. Critical comparison to the tetracycline class appears to be lacking in the literature.

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