AburaMycin A, NSC 131187 CAS 6992-70-7 for Superior Antibacterial Treatment

Product Description:

Product Name: AburaMycin A, NSC 131187 CAS NO: 6992-70-7

Synonyms:

AburaMycin A, NSC 131187;

ChroMoMycin A2;

Chemical & Physical Properties:

Appearance: Solid

Assay :≥99.00%

Density: 1.40±0.1 g/cm3(Predicted)

Boiling Point: 1154.0±65.0℃(Predicted)

Pka: 4.54±0.60(Predicted)

Flash Point: 309.5℃

Index of Refraction: 1.603

Chromomycin A2 is a minor, more hydrophobic analogue of the chromomycin complex of the aureolic acid class. Chromomycin A2 was originally isolated from S. aburaviensis and named aburamycin. Chromomycin A2 exhibits a broad biological profile as an antibacterial, antifungal and antitumor agent. Chromomycin A2 has not been extensively studied. Chromomycin A2 is an aureolic acid that has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs). Chromomycin A2 halts the cell cycle in the G0/G1 phase and increases the protein levels of LC3A and LC3B in MALME-3M melanoma cells. This indicates that it induces autophagy. It also increases the levels and promoter activity of the autophagic proteins ATG7 and ATG10 and reduces cell viability to 50% in human SCC-11 squamous cell carcinoma cells when used at a concentration of 30 nM.

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