PICEATANNOL CAS 10083-24-6 API Active Pharmaceutical Ingredient

Product Description:

Product Name: PICEATANNOL CAS NO: 10083-24-6

Synonyms:

(E)-4-[2-(3,5Dihydroxyphenyl)ethenyl]1,2-benzenediol;

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol;

3,3',4,5'-Tetrahydroxy-trans-stilbene;

Chemical & Physical Properties:

Appearance: Light tan to yellow powder

Assay :≥99.00%

Density: 1.468 g/cm3

Boiling Point: 507.3℃ at 760 mmHg

Melting Point: 223-227℃

Flash Point: 252.2℃

Refractive Index: 1.8

Storage Condition: 2-8℃

Vapor Pressure: 6.51E-11mmHg at 25℃

Safety Information:

Safety Statements: S24/25

HS Code: 2907299090

WGK Germany: 3

Piceatannol is a stilbenoid, a type of phenolic compound. Piceatannol is a selective inhibitor of protein tyrosine kinase Syk. It could inhibit ICa,L, Ito, IKr, Ca2+ transients and Na+-Ca2+ exchange except IK1. Shows multiple biological activities such as anti-inflammatory, antiproliferative and immunomodulatory effects.In vitro: The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-κB. The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-κB activation was also suppressed in lymphocyte and epithelial cells. Piceatannol also inhibited NF-κB activated by H2O2, PMA, LPS, okadaic acid, and ceramide.

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