DOPAC CAS 102-32-9 API Active Pharmaceutical Ingredient

Product Description:

Product Name: DOPAC CAS NO: 102-32-9

Synonyms:

Catechol-4-acetic Acid;

Benzeneacetic acid, 3,4-dihydroxy-;

3,4-dihydroxy-1-benzeneacetic acid;

Chemical & Physical Properties:

Appearance: Beige to light brown crystalline powder

Assay :≥99.00%

Density: 1.478g/cm3

Boiling Point: 418.4℃ at 760mmHg

Melting Point: 126-130℃

Flash Point: 221℃

Refractive Index: 1.628

Water Solubility: Soluble in water and methanol

Stability: Stable under normal temperatures and pressures

Storage Condition: -20℃

Vapor Pressure: 0mmHg at 25℃

Safety Information:

RTECS: AH0590000

Safety Statements: S26-S36

HS Code: 2918290000

WGK Germany: 3

Risk Statements: R36/37/38

Hazard Code: Xi

Symbol: GHS07

Signal Word: Warning

Hazard Declaration: H315; H319; H335

Caution Statements: P261; P305 + P351 + P338

3,4-Dihydroxyphenylacetic acid (DOPAC) is a metabolite of the neurotransmitter dopamine.

Dopamine can be metabolized into one of three substances. One such substance is DOPAC. Another is 3-methoxytyramine (3-MT). Both of these substances are degraded to form homovanillic acid (HVA). Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA. The third metabolic end-product of dopamine is norepinephrine (noradrenaline).

DOPAC can be oxidized by hydrogen peroxide, leading to the formation of toxic metabolites which destroy dopamine storage vesicles in the substantia nigra. This may contribute to the failure of levodopa treatment of Parkinson's disease. A MAO-B inhibitor such as selegiline or rasagiline can prevent this from happening.

Biodegradation of dopamine; It can also be found in the bark of Eucalyptus globulus.

This product has been synthesized (52% yield) from 4-Hydroxyphenylacetic acid via aerobic biotransformation using whole cell cultures of Arthrobacter protophormiae.

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