Ceramides CAS 100403-19-8 API Active Pharmaceutical Ingredient

Product Description:

Ceramides CAS:100403-19-8

Synonyms:

CAPROYL SPHINGOSINE;

HYDROXYCAPROYL PHYTOSPHINGOSINE;

LACTOYL PHYTOSPHINGOSINE;

Chemical & Physical Properties

Appearance:White to light yellow powder

Assay: NLT99%

storage condition:-20°C

Safety Information

Risk Statements: Xi

Hazard Codes:/

HS Code:/

Application: 1. Anti-tumor Many tumors are related to the anti-apoptosis of cells, so the treatment of tumors is mainly to induce apoptosis. Traditional cancer treatment mainly relies on drug chemotherapy, that is, drug induced apoptosis, but ceramide treatment of cancer is different from general drugs, it can directly act on apoptosis signal transduction pathway, thereby causing apoptosis. Therefore, ceramides open up a new therapeutic option for anti-tumor therapy. Ceramides are divided into endogenous ceramides and exogenous ceramides. In the process of tumor treatment, the concentration of intracellular ceramide can be increased by directly adding exogenous ceramide or promoting the synthesis of endogenous ceramide to induce cell apoptosis and achieve the purpose of tumor treatment. When cells are stimulated by various external conditions, endogenous ceramide synthesis begins, which promotes the increase of intracellular ceramide concentration and may induce a series of physiological and pathological reactions such as apoptosis. Therefore, ceramide is considered to be a lipid that can inhibit tumor cells. 2. Prevention and treatment of cardiovascular diseases Vascular endothelial cells are the first barrier of the cardiovascular system, and the integrity and endocrine function of vascular endothelial cells are related to the normal function of the cardiovascular system. When the body is in a state of disease, the expression of a large number of inflammatory factors in the body will increase sharply, and the overexpression of inflammatory factors will affect the integrity and endocrine function of endothelial cells, and even lead to apoptosis of endothelial cells in severe cases. Ceramide plays a significant role in inducing apoptosis of endothelial cells. It can be seen that ceramide plays a very important role in regulating the integrity and endocrine function of endothelial cells. Ceramide induces apoptosis of vascular endothelial cells through Fas pathway, which plays a very important role in studying the mechanism of ceramide induced apoptosis of vascular endothelial cells. 3. Anti-inflammatory TNF (tumor necrosis

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