Pitavastatin Calcium CAS 147526-32-7 Improve Cholesterol Levels

Product Description:

Product Name: Pitavastatin calcium CAS NO: 147526-32-7

Synonyms:

calcium,(E,3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate;

Livazo;

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-hept-6-enoic acid;

Pitavastatin hemicalcium;

Chemical & Physical Properties:

Appearance: White to off-white powder

Assay :≥99.00%

Boiling Point: 692℃ at 760 mmHg

Flash Point: 372.3℃

Safety Information:

HS Code: 2933499090

Safety Statements: S24/25

A competitive inhibitor of HMG-CoA reductase. Antilipemic. Pitavastatin calcium (Livalo) is a novel member of the medication class of statins. Pitavastatin, launched for the treatment of hypercholesterolemia, belongs to the family of second-generation statins, also referred to as superstatins due to their improved efficacy as cholesterol lowering agents. Like other statins, pitavastatin reduces plasma cholesterol levels by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis in the liver. It is a more potent inhibitor of HMG-CoA reductase than the previously marketed statins and has the potential benefit of not undergoing significant metabolism by CYP3A4. Pitavastatin is synthesized in a multi-step sequence, including the key step of introducing the dihydroxyheptenoate side chain by cross-coupling of a 3-iodoquinoline intermediate with an alkenylborane reagent. Unlike rosuvastatin, pitavastatin has a high oral bioavailability (～80%).

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