1-Cyclopropyl-6-fluoro-1,4-dihydro-8-m-ethoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid CAS 112811-59-3

Product Description:

Product Name:

1-Cyclopropyl-6-fluoro-1,4-dihydro-8-m-ethoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid CAS NO: 112811-59-3

Synonyms:

Gatifloxacin;

Gatifloxacin API;

PD 135432;

Chemical & Physical Properties:

Appearance: White powder

Assay :≥99.00%

Density: 1.386 g/cm3

Boiling Point: 607.8℃at 760 mmHg

Melting Point: 162℃

Flash Point: 321.4℃

Refractive Index: 1.616

Storage Condition: Store at 0-5℃

Vapor Pressure: 1.26E-15mmHg at 25℃

Safety Information:

RTECS: BT1750000

Safety Statements: S26; S36/37/39; S37/39

HS Code: 2933990090

Risk Statements: R20/21/22; R36/37/38

Hazard Code: Xn

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.Target: AntibacterialGatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Gatifloxacin had activity equal to that of tosufloxacin and activity more potent than those of norfloxacin, ofloxacin, c-iprofloxacin, and sparfloxacin against the second-step mutants (grlA gyrA; gatifloxacin MIC range, 1.56 to 3.13 microg/ml) and had the most potent activity against the third-step mutants (grlA gyrA grlA; gatifloxacin MIC range, 1.56 to 6.25 microg/ml), suggesting that gatifloxacin possesses the most potent inhibitory activity against singly mutated topo IV and singly mutated DNA gyrase among the quinolones tested.Ophthalmic gatifloxacin 0.3% is at least as effective as c-iprofloxacin at healing corneal ulcers infected with Pseudomonas aeruginosa when gatifloxacin is administered less frequently than c-iprofloxacin. Trends favored gatifloxacin in fluorescein retention scores .Clinical indications: Bacterial infection FDA Approved Date: Toxicity: Hepatotoxicity; Acute pancreatitis ; Torsades de pointes

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