Voriconazole CAS 137234-62-9

Product Description:

Product Name: Voriconazole CAS NO: 137234-62-9

Synonyms:

(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;

(2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol;

Voriconazole 2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;

Chemical & Physical Properties:

Appearance: White to off white crystalline powder

Assay :≥99.00%

Density: 1.42 g/cm3

Boiling Point: 508.6℃ at 760 mmHg

Melting Point: 127-130℃

Flash Point: 261.4℃

Refractive Index: 1.616

Vapor Pressure: 3.63E-11mmHg at 25℃

Safety Information:

Safety Statements: S26-S36

HS Code: 2933990090

Risk Statements: R22; R36/38

Hazard Codes: Xn;T;F

Hazard Class: 6.1

Packing Group: III

Voriconazole (brand name Vfend, Pfizer) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections. Voriconazole was introduced in the US for the treatment of acute invasive aspergillosis, candidosis and other emerging fungal infections seen in immuno compromised patients. It can be synthesized in 3 steps by reaction of readily available 6-( 1 -bromoethyl)-4-chloro-5 fluoropyrimidine with I-(2,4-difluorophenyl)-2-(1,2,4-triazol-I-yl) ethanone in the presence of zinc metal.

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