Manidipine Dihydrochloride CAS 89226-75-5

Product Description:

Product Name: Manidipine Dihydrochloride CAS NO: 89226-75-5

Synonyms:

4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride;

cv-4093dihydrochlorde;

franidipinehydrochloride;

Chemical & Physical Properties:

Appearance: White to pale yellow solid

Assay :≥99.00%

Boiling Point: 722℃ at 760 mmHg

Melting Point211℃ (dec.)

Water Solubility: Soluble in DMSO. Slightly soluble in water and ethanol /n

Storage: Refrigerator

Solubility: DMSO (Sparingly, Heated), Methanol (Slightly)

Safety Information:

HS Code: 2942000000

RIDADR: UN 2811 6.1/PG III

RTECS: US7975300

Hazard Class: 6.1

Packing Group: III

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.

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