Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 123318-82-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15DAY
Payment Terms: L/C,D/A,D/P,Western Union,T/T,MoneyGram
Supply Ability: G,KG,TON
Appearance:: |
White Solid |
CAS NO:: |
123318-82-1 |
Molecular Formula:: |
C10H11ClFN5O3 |
Molecular Weight:: |
303.67700 |
EINECS NO:: |
631-422-9 |
MDL NO:: |
MFCD00871077 |
Appearance:: |
White Solid |
CAS NO:: |
123318-82-1 |
Molecular Formula:: |
C10H11ClFN5O3 |
Molecular Weight:: |
303.67700 |
EINECS NO:: |
631-422-9 |
MDL NO:: |
MFCD00871077 |
Product Description:
Product Name: Clofarabine CAS NO: 123318-82-1
Synonyms:
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol;
2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine;
2-chloro-2'-arabino-fluoro-2'-deoxyadenosine;
Chemical & Physical Properties:
Appearance: White solid
Assay :≥99.00%
Density: 2.12 g/cm3
Boiling Point: 550℃ at 760 mmHg
Melting Point: 228-231℃
Flash Point: 286.4℃
Refractive Index: 1.843
Vapor Pressure: 3.19E-15mmHg at 25℃
Safety Information:
RTECS: DP5550000
Hazard Class: 8
Safety Statements: S26; S36; S45; S36
WGK Germany: 3
Packing Group: III
RIDADR: UN 2735 8/PG 3
Risk Statements: R36/37/38; R20/21/22
Hazard Codes: Xi; C
Caution Statements: P264; P301 + P310
Signal Word: Danger
Symbol: GHS06
Hazard Declaration: H300
Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.
Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.IC50 Value: 65 nMTarget: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It is phosphorylated intracellularly, which inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factor, which activate apoptosis.in vivo: Clofarabine is used for treating relapsed or refractory acute lymphoblastic leukaemia (ALL) in children, after at least two other types of treatment have failed.
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