Safinamide CAS 133865-89-1

Product Description:

Product Name: Safinamide CAS NO: 133865-89-1

Synonyms:

Safinamide ,Safinamide base;

Safinamide Intermediate 2;

(S)-(+)-2-[4-(3-Fluorobenzyloxy)benzylamino]propanamice methansulfonate;

Chemical & Physical Properties:

Appearance: White to off-white solid

Assay :≥99.00%

Density: 1.189 g/cm3

Boiling Point: 476.7℃ at 760 mmHg

Flash Point: 242.1±27.3℃

Refractive Index: 1.569

Vapor Pressure: 2.98E-09mmHg at 25℃

Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.IC50 value: 98 nM [1]Target: MAO-BSafinamide (EMD 1195686; FCE 26743; ) is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide (EMD 1195686; FCE 26743; ) is voltage-dependent sodium and calcium channel blocker. Safinamide (EMD 1195686; FCE 26743; ) appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

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