Lubiprostone CAS 136790-76-6

Product Description:

Product Name: Lubiprostone CAS NO: 136790-76-6        

Synonyms:

13,14-Dihydro-15-keto-PGD2;

13,14-Dihydro-15-ketoprostadlandin D2;

13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1;

Chemical & Physical Properties:

Appearance: White, odorless crystals or crystalline powder

Assay :≥99.00%

Density: 1.175 g/cm3

Boiling Point: 532.3℃ at 760 mmHg

Melting Point: 56-59℃

Flash Point: 275.7℃

Refractive Index: 1.486

Vapor Pressure: 1.49E-13mmHg at 25℃

Safety Information:

HS Code: 2918990090

Signal Word: Warning

Caution Statements: P261; P305 + P351 + P338

Symbol: GHS07

Hazard Declaration: H315; H319; H335

Lubiprostone (rINN, marketed under the trade name Amitiza among others) is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation.

It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. It is very expensive as of 2012. Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation.

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