MIZORIBINE CAS 50924-49-7

Product Description:

Product Name: MIZORIBINE CAS NO: 50924-49-7             

Synonyms:

Bredinine;

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide;

1-(β-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide;

Chemical & Physical Properties:

Appearance: White to off-white crystalline powder

Assay :≥99.00%

Density: 2.06 g/cm3

Boiling Point: 755.9℃ at 760 mmHg

Melting Point: >200℃

Flash Point: 410.9℃

Refractive Index: 1.794

Stability: Stable at normal temperatures and pressures.

Storage Condition: 2-8℃

Safety Information:

Safety Statements: S53-22-26-36/37/39-45

Risk Statement: R46

Hazard Code: T

Caution Statements: P201; P261; P305 + P351 + P338; P308 + P313

Signal Word: Danger

Symbols: GHS07, GHS08

Hazard Declaration: H315; H319; H335; H360

Nucleoside antibiotic with cytotoxic and immunosuppressive activity. Imidazole made bean is also called Mr. Penicillin, cloth tired di ning, imidazole, optimal green indican, is by the Japanese scholar agms was isolated from soil of ascomycetes the M - 2166 strains isolated culture filtrate Chemicalbook out a imidazoles nucleoside, to inhibit nucleic acid purine metabolites synthesis pathway, mainly for the inhibition of before and after renal transplantation rejection, It is also used for liver transplantation and autoimmune diseases. In recent years, it has also been used in clinic as an anti-rejection drug for kidney transplantation. Compared with the similar drug azathioprine, midazolibine has less hepatotoxicity and bone marrow inhibition. The main adverse reactions of midazolibine are gastrointestinal reactions, blood system disorders and allergic symptoms, and bone marrow inhibition and acute renal failure are occasionally seen.

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