Prostaglandin E2 CAS 363-24-6

Product Description:

Product Name: Prostaglandin E2 CAS NO: 363-24-6            

Synonyms:

(Z)-7-((1R,2R,3R)-3-Hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)hept-5-enoic acid;

Dinoprostone;

Cerviprost;

Chemical & Physical Properties:

Appearance: White to pale yellowish-cream powder

Assay :≥99.00%

Density: 1.148 g/cm3

Boiling Point: 530.071℃ at 760 mmHg

Melting Point: 66-68℃

Flash Point: 288.452℃

Water Solubility: Insoluble

Stability: Stable under normal temperatures and pressures. Light sensitive.

Storage Condition: -20℃

Vapor Pressure: 0mmHg at 25℃

Safety Information:

RTECS: UK8000000

Safety Statements: S53-S22-S26-S36/37/39

WGK Germany: 3

Risk Statements: R60; R22

Hazard Code: T

Signal Word: Danger

Symbols: GHS07, GHS08

Hazard Declaration: H302; H360

Caution Statements: P201; P308 + P313

The most common and biologically potent of mammalian prostaglandins. Oxytocic; abortifacient.

Denoprosterone is a white to white solid, natural prostaglandin (PG), which has contractive effect on uteri of all stages of pregnancy, but the sensitivity of uteri of all stages of pregnancy to PGE2 is not consistent, and the full-term uterine reaction is the most sensitive. Uterine stimulants. For pregnancy oxytocin, induction of labor in the second trimester and treatment of abortion, preoperative cervical dilation. In a small number of cases, chills, vomiting, and mild diarrhea may be spontaneously relieved within a short time, or may be easily controlled by Chemicalbook treatment. Intravenous inflammation was similar in intravenous drip, and disappeared spontaneously after drug withdrawal. During the course of medication, the uterine contractions should be closely observed and the dosage should be adjusted at any time to prevent uterine rupture caused by excessive uterine contractions. One of the most biologically active prostaglandins, induces cervical maturation and delivery, mediates bradykinin-induced vasodilation, and regulates adenylate cyclase. Tumor cells overexpressing cyclooxygenase-2 showed increased invasiveness, angiogenesis, and apoptosis resistance, possibly due to PGE2-induced angiogenic factor Chemicalbook and the stabilization of the anti-apoptotic protein Survivin. PGE2 has a mixed effect on the immune system. It inhibits T cell activation in vitro, indicating that it is an immunosuppressant. In vivo, however, it affects the amplification of Th17 subsets and the differentiation of Th1 subsets in T helper cells, suggesting that it is an immune-activator.

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