Indapamide CAS 26807-65-8 for Managing Fluid Retention and Hypertension

Product Description:

Product Name: Indapamide CAS NO: 26807-65-8                                       

Synonyms:

4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoyl-benzamid;

3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamid;

N-(4-Chloro-3-sulfamoylbenzamido)-2-methylindoline;

Chemical & Physical Properties:

Appearance: Crystalline solid

Assay :≥99.0%

Density: 1.51 g/cm3

Melting Point: 160-162℃

Refractive Index: 1.693

Stability: Stable at normal temperatures and pressures.

Water Solubility: Soluble in ethanol. Insoluble in water

Safety Information:

RTECS: CV2451200

HS Code: 2935009090

WGK Germany: 2

Indapamide has both diuretic and calcium antagonistic effects. By inhibiting Na+ reabsorption at the proximal end of distal conflexion tubules, it produces diuretic effect and also blocks Ca2+ influx. It has a high selectivity to vascular smooth muscle, dilates peripheral small vessels and produces hypotensive effect. But the effect on vascular smooth muscle stronger diuretic effect, below the diuretic doses can step-down, higher doses showed diuretic effect, but no thiazide diuretic shortcomings, namely not cause orthostatic hypotension, flush and reflective tachycardia, on blood picture, metabolism of blood fat, sugar and renal function also had no obvious effect, therapeutic doses of heart rate, cardiac output, no significant changes in electrocardiogram (ecg) were It has no obvious effect on central nervous system and autonomic nerve. Oral administration of 2 ~ 3 chemicalbook H produced a hypotensive effect, which was maintained for 24h. Diuretic effect appeared at 3h and reached its maximum effect at 4 ~ 6h. Different from other diuretics, this product is highly fat soluble. After oral absorption, the plasma concentration in liver and kidney is the highest, and the concentration in heart, lung, muscle and fat is low. This product is mainly excreted from the kidney in the form of metabolites and 5% of the prototype. Indapamide is suitable for mild and moderate primary hypertension, can also be used for congestive heart failure caused by water sodium retention, with renal failure are also applicable to the patients with high blood pressure, diabetes, hyperlipidemia, use antihypertensive effect is remarkable, and beta blockers used curative effect is better, because this drug has diuretic effect, can cause hypokalemia, can complement potassium at the same time.

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