Homovanillic Acid CAS 306-08-1 White To Off-white Crystalline Powder

Product Description:

Product Name: Homovanillic acid CAS NO: 306-08-1                                    

Synonyms:

Vanilacetic acid;

2-(4-Hydroxy-3-m-ethoxyphenyl)acetic acid;

4-Hydroxy-3-m-ethoxyphenylacetic acid;

Chemical & Physical Properties:

Appearance: White to off-white crystalline powder

Assay :≥99.0%

Density: 1.307g/cm3

Boiling Point: 368.7℃ at760mmHg

Melting Point: 141-145℃

Flash Point: 151.9℃

Water Solubility: Soluble

Stability: Stable under normal temperatures and pressures.

Storage Condition: Store at RT.

Safety Information:

Safety Statements: S26-S36

HS Code: 2918990090

WGK Germany: 3

Risk Statements: R36/37/38

Hazard Code: Xi

Hazard Declaration: H315; H319; H335

Caution Statements: P261; P305 + P351 + P338

Signal Word: Warning

Symbol: GHS07

Homovanillic acid (HOC6H3(OCH3)CH2COOH; synonyms: 3-m-ethoxy-4-hydroxyphenyl acetic acid; HVA; 4-hydroxy-3-m-ethoxy-benzeneacetic acid; 4-hydroxy-3-m-ethoxyphenylacetic acid) is a major catecholamine metabolite and is produced by the consecutive action of monoamine oxidase and catechol-O-methyl transferase on dopamine. It is used as a reagent to detect oxidative enzymes, and is associated with dopamine levels in the brain.

In psychiatry and neuroscience, brain and cerebrospinal fluid levels of HVA are measured as a marker of metabolic stress caused by 2-deoxy-D-glucose. HVA presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.

Fasting plasma levels of HVA are known to be higher in females than in males. This does not seem to be influenced by adult hormonal changes, as the pattern is retained in the elderly and post-menopausal as well as transsexuals according to their genetic sex, both before and during cross-sex hormone administration. Differences in HVA have also been correlated to tobacco usage, with smokers showing significantly lower amounts of plasma HVA.

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