Rifamycin S CAS 13553-79-2 for Bacterial Infections

Product Description:

Product Name: Rifamycin S CAS NO: 13553-79-2  

Synonyms:

O1,O4-didehydro-rifamycin;

NCI 144-130;

1,4-Dideoxy-1,4-dihydro-1,4-dioxorifamycin;

Chemical & Physical Properties:

Appearance: Yellow orange crystalline powder

Assay :≥98.0%

Density: 1.33 g/cm3

Boiling Point: 917.4℃ at 760 mmHg

Melting Point: 179-181℃ (dec.)

Flash Point: 508.6℃

Refractive Index: 1.605

Vapor Pressure: 0mmHg at 25℃

Safety Information:

HS Code: 2941903000

RTECS: KD1925000

Toxicity: LD50 in mice (mg/kg): 122 i.v.; 258 i.p.; 3000 orally (Sensi, 1964)

The rifamycins are a group of chemically related antibioticsobtained by fermentation from cultures of Streptomycesmediterranei. They belong to a class of antibiotics called theansamycins that contain a macrocyclic ring bridged acrosstwo nonadjacent positions of an aromatic nucleus. The termansa means “handle,” describing well the topography of thestructure. The rifamycins and many of their semisynthetic derivativeshave a broad spectrum of antimicrobial activity.They are most notably active against Gram-positive bacteriaand M. tuberculosis. However, they are also active againstsome Gram-negative bacteria and many viruses. Rifampin, asemisynthetic derivative of rifamycin B, was released as anantitubercular agent in the United States in 1971. A secondsemisynthetic derivative, rifabutin, was approved in 1992 forthe treatment of atypical mycobacterial infections.

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