Red-violet Crystalline Powder Rifabutin CAS 72559-06-9

Product Description:

Product Name: Rifabutin CAS NO: 72559-06-9                      

Synonyms:

1',4-didehydro-1-desoxi-1,4-di-hydro-5'-(2-methyl-propyl)-1-oxo-rifamycin;

4-deoxo-3,4-[2-spiro(N-isobutyl-4-p-iperidyl)-2,5-dihydro-1H-imidazo]-rifamicin S;

antibioticlm427;

Chemical & Physical Properties:

Appearance: Red-violet crystalline powder

Assay :≥99.0%

Density: 1.339g/cm3

Boiling Point: 969.589℃ at 760 mmHg

Melting Point: 169-171℃

Flash Point: 540.188℃

Water Solubility: 0.19g/L(temperature not stated)

Refractive Index: 1.623

Storage Condition: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Safety Information:

HS Code: 2941903000

WGK Germany: 3

RTECS: VJ6700000

Rifabutin (Rfb) is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare.It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system. Rifamycins are antibiotics that inhibit DNA-dependent RNA polymerases and are usually bactericidal against Gram-positive bacteria but bacteriostatic against Gram-negative bacteria. Rifamycins are also effective against Mycobacterium species, including M. tuberculosis. Rifabutin is a broad-spectrum rifamycin antibiotic that has applications against tuberculosis, H. pylori, M. avium complex, Chlamydia, and other bacteria. It is also useful in co-infections with human immunodeficiency virus, including tuberculosis.

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